Development and validation of the method for determination of amitraz in honey using high-performance liquid chromatography with mass spectrometric detection
نویسندگان
چکیده
Method for determination of the insecticide amitraz residual content in honey has been developed and validated. The method is selective, express easy-to-perform. technique based on extraction from alkalized aqueous solutions with n-hexane quantitative by high-performance liquid chromatography mass spectrometric detection. Validation was performed using three types at levels application 6, 120 220 µg/kg. limit quantification 0.9 µg/kg, calibration curves were linear concentration range 2.5 to 125.0 ng/mL (the corresponding analyte 5.0 250.0 µg/kg), relative values standard deviations repeatability within-laboratory reproducibility did not exceed 3.4 5.9 %, respectively, bias varied –8.2 5.6 expanded uncertainty estimates results ranged 12 16 % (P = 0.95). Instrumental quantification, overall efficiency process robustness also evaluated during validation process.
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ژورنال
عنوان ژورنال: ????? ???????????? ???????? ????? ????????
سال: 2022
ISSN: ['2524-2377', '2524-2369']
DOI: https://doi.org/10.29235/1561-8331-2022-58-4-387-397